臧敬五简历
简历概括
学术方面: 布鲁塞尔大学神经免疫学博士, 美国哈佛医学院博士后. 美国Baylor医学院神经学和免疫学教授, 中国科学院和上海交通大学医学院教授. 长期致力于多发性硬化及自身免疫性疾病的基础及临床研究。在《科学》、《自然-免疫》,《自然-医学》等国际知名学术刊物发表了160多篇学术论文、综述及专著。
临床方面: 在美国Baylor医学院完成了美国临床医师训练，获美国临床医师执照. 有丰富的基础-临床转化性研究和新药临床研究经验.
管理方面: 美国Baylor医学院多发性硬化研究中心主任。回国后，创建了中国科学院健康科学研究所(首任所长)，中国科学院上海巴斯德研究所(首任中方所长), 曾任上海交通大学基础医学院院长, 上海市免疫学研究所所长.
新药研发方面: 早年创建了美国Opexa Pharmaceuticals生物技术公司(上市). 2007年起任葛兰素史克GSK 全球高级副总裁，中国研发中心总裁.创建了GSK中国研发中心. 该中心已发展成为一个凝聚了460多名各国科学家及临床研究人员的国际一流的自主创新药物研发机构. 2012年兼任公司神经系统药物研发的全球总负责人, 完成了以上海为核心，链接美国、英国、新加坡的神经系统药物研发从药物靶标筛选等前期基础研究到后期临床试验的全球布局。创造了跨国药企在中国开展创新药物全程研发的先例.

医学学位
1979年 – 1984年 医学学位，上海第二医科大学，
1984年 – 1986年 研究生, 上海市免疫学研究所，上海第二医科大学
1986年 – 1990年 神经免疫学博士, 比利时布鲁塞尔大学，
1991年 – 1992年 博士后, 美国哈佛医学院.

美国医师执照和临床实验研究证书
美国医师执照，得克萨斯州医学委员会颁发
美国注册临床研究者CTI (ACRP/FDA)
美国临床实验室认证CLIA
美国医师执照考试III，1999年, 美国ECFMG，1996年, 美国医师执照考试II，1996年, 美国医师执照考试I，1995年

美国临床经验
6/2000 – 6/2002多发性硬化症研究中心，美国贝勒医学院神经内科医师.
6/1998 – 6/1999美国贝勒医学院神经内科和全科医学住院医师.

学术任职
2010, 香港大学李嘉诚医学院名誉教授(解剖学系)
2007, 美国贝勒医学院客座教授, 健康科学研究所客座教授
1/2007 – 6/2007, 上海交通大学基础医学院院长，教授
2002 – 2007, 中国科学院健康科学研究所, 首任所长, 教授
2001 – 2007, 上海市免疫学研究所所长, 教授
2004 – 2006, 中国科学院上海巴斯德研究所,首任中方所长, 教授
2001 – 2007, 美国贝勒医学院神经学,免疫学教授
1996 – 2007, 贝勒医学院多发性硬化研究中心主任, 神经免疫学实验室主任
1996 – 2000, 美国贝勒医学院神经学,免疫学副教授
1994 – 1996, 比利时林堡大学医学院客座教授
1992 – 1996, 比利时L.威廉姆斯研究所多发性硬化和免疫学研究部主任
1986 – 1991, 比利时布鲁塞尔大学和L. 威廉姆斯研究所研究员

公司任职
1999 – 2002, 美国Opexa Pharmaceuticals 生物技术公司创始人,首席科学管.
2007 – 2013, GSK全球高级副总裁,中国研发中心总裁兼全球神经系统药物研发总裁(2012-2013)
2013 -2016, 先声药业首席科学官,百家汇科技创业社区总裁
2016 -2017 ,南京三境生物科技公司创始人，董事长，首席执行官
2017 -至今,天境生物科技公司董事长，首席执行官

学会, 编委, 国际评审委员会
美国科学进步协会, 美国免疫学家协会, 美国神经病学学会, 中国免疫学会执行委员会委员, 1996-2007期间担任多个国际学术杂志编委, 意大利多发性硬化症协会国际评委, 新西兰神经学会国际评委, 以色列科学基金会评委, 美国退伍军人事务医疗中心评委, 美国国立卫生研究院奖学金评委, 美国国立卫生研究院评委, NIH GCRC评委. 审稿：美国科学院院刊, 美国免疫学杂志, 病毒学杂志; 脑, 神经生物学疾病杂志，神经免疫学杂志，细胞免疫学杂志，国际免疫学杂志, …

发明专利
T细胞受体的VDJ序列和其检测方法, 美国专利＃ 6303314
交叉反应性T细胞的分离和鉴定, PCT/US03/41284美国20060204495
基因表达谱技术治疗多发性硬化症的评价, US 20050064483
自体T细胞疫苗的材料和方法, 美国20050186192
T细胞受体CDR3序列和方法，用于检测和治疗类风湿关节炎,
美国20050010030, CN03818631.4, CN200310120573.X
OPN抑制剂类风湿关节炎中的应用, CN200510024203.5
可溶性协同信号分子在检测类风湿关节炎中的用途, CN200610029799.1
β-抑制蛋白1在调节Ţ细胞存活和自身免疫中的应用, CN 200710041559.9
类风湿关节炎T细胞疫苗, PCT/US07/72277

奖项和荣誉
1991年美国国家多发性硬化协会奖
1993年比利时国家临床免疫学成就奖
1994年意大利第三届国际自身免疫性疾病及遗传学奖
1999年美国国家多发性硬化症协会乔治-布什研究奖
2001年中国海外青年学者合作研究基金
2002年中国科学院研究所百人计划
2003年上海首席科学家计划
2005年上海市浦江人才计划
2005年上海白玉兰奖
2011年上海白玉兰金奖
已发表学术论文
1. Wim Weber, Jingwu Zhang and Wim Buurman. Human myelin basic protein-specific cytotoxic T lymphocyte clones are HLA class II restricted. Transplantation Proceedings 20: 232-234, 1988.
2. *Jingwu Zhang, Wim Weber, Jannie Borst, Arthur Vandenbark and Jef Raus. A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule. Journal of Immunology 142: 3917-3922, 1989.
3. *Jingwu Zhang, Arthur Vandenbark, Marie-Paule Jacobs, Halina Offner and Jef Raus. Murine monoclonal anti-myelin basic protein antibodies inhibit proliferation and cytotoxicity of MBP-specific human T cell clones. Journal of Neuroimmunology 24: 87-94, 1989.
4. Jingwu Zhang, Jos Lambrechts, Harri Heyligen, Arthur Vandenbark and Jef Raus. Human B cell lines secreting IgM antibody specific for myelin basic protein. Journal of Neuroimmunology 23: 249-256, 1989.
5. Jingwu Zhang, Paula Henderikx, Chin Ying Robert Medaer and Jef Raus. A method to establish antibody secreting B cell lines and simultaneously perform frequency analysis. Journal of Immunological Methods 123: 153-154, 1989.
6. Jingwu Zhang, Chi-Hsin Chou, George Hashim, Robert Medaer and Jef Raus. Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients. Cellular Immunology 129: 189-198, 1990.
7. Jingwu Zhang, Chin Ying, Paula Henderikx, Robert Medaer, Chi-Hsin Chou and Jef Raus. Antibodies to myelin basic protein and measles virus in multiple sclerosis: precursor frequency analysis of the antibody producing B cells. Autoimmunity 11: 27-34, 1991.
8. Avraham Ben-Nun, Roland Liblau, Lydia Cohen, Dan Lehmann, Elisabeth Tournier-Lasserve, Anthony Rosenzweig, Jingwu Zhang, Jef Raus and Marie-Anne Bach. Restricted T cell receptor Vbeta gene usage by myelin basic protein-specific T cell clones in multiple sclerosis: predominant genes vary in individuals. Proceedings of the National Academy of Science 88: 2466-2470, 1991.
9. Jingwu Zhang, Marleen Schreurs, Robert Medaer and Jef Raus. Regulation of myelin basic protein-specific helper T cells in multiple sclerosis: generation of suppressor T cell lines. Cellular Immunology 139: 118-130, 1992.
10. **Jingwu Zhang, Robert Medaer, George Hashim, Chin Ying, Ella van den Berg-Loonen and Jef Raus. Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Annals of Neurology 32: 330-338, 1992.
11. Ying Chin, J. Janssens, E. Smeyers, J. Bleus, Jingwu Zhang and J. Raus. Large scale expansion of human tumor infiltrating lymphocytes with surface-modified stimulator cells for adoptive immunotherapy. Anticancer Research 12: 733-736, 1992.
12. Henry Oettinger, Ahmad Al-Sabbagh, Jingwu Zhang, Jannie LaSalle, Howard Weiner and David Hafler. Biological activity of recombinant human myelin basic protein. Journal of Neuroimmunology 44: 157-162, 1993.
13. ***Jingwu Zhang, Robert Medaer, Piet Stinissen, David Hafler, Jef Raus. MHC-restricted depletion of human myelin basic-protein reactive T-cells by T-cell vaccination. Science, 261(5127):1451-1454, 1993.
14. David Hafler, Jingwu Zhang, J. LaSalle, C. Donnelly, Howard Weiner and Kai Wucherpfennig. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clinical and Experimental Rheumatology 11: S39-40, 1993.
15. Ying Chin, Jaak Janssens, Josianne Bleus, Jingwu Zhang, Jef Raus. In vivo distribution of radio-labeled tumor infiltrating lymphocytes in cancer patients. In vivo 7:27-30, 1993.
16. ***Jingwu Zhang, Silva Markovic, Blishda Lacet, Jef Raus, Howard Weiner and David Hafler. Increased frequency of interleukin 2-responsive T-cells specific for myelin basic-protein and proteolipid protein in peripheral-blood and cerebrospinal-fluid of patients with multiple-sclerosis. Journal of Experimental Medicine 179: 973-984, 1994.
17. *Kai Wucherpfennig, Jingwu Zhang, Chris Witek, Makoto Matsui, Yalda Modabber, Kohei Ota and David Hafler. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. Journal of Immunology 152: 5581-5592, 1994.
18. *Hans Deckmyn, Jingwu Zhang, E. Van Houtte and J. Vermylen. Production and molecular sequence of an inhibitory human IgM autoantibody directed against platelet glycoprotein Ia/Iia. Blood 84: 1968-1974, 1994.
19. Ying Chin, J. Janssens, J. Bleus, Jingwu Zhang and J. Raus. Cellular and molecular analysis of tumor infiltrating lymphocytes from human breast cancer at clonal level. Oncology Reports 1: 577-583, 1994.
20. Ying Chin, J. Janssens, J. Bleus, Caroline Vandevyver, Jingwu Zhang and J. Raus. T cell receptor Vβ usage of tumor infiltration lymphocyte lines cloned from human breast tumor and melanoma. International Journal of Oncology 7: 147-153, 1995.
21. Jingwu Zhang, Caroline Vandevyver, Piet Stinissen, Ella van den Berg-Loonen and Jef Raus. Activation and clonal expansion of human myelin basic protein-reactive T cells by bacterial superantigens. Journal of Autoimmunity 8 (4): 615-632, 1995.
22. *Caroline Vandevyver, Nadja Mertens, Peter Van den Elsen, Jef Raus and Jingwu Zhang. Clonal expansion of myelin basic protein-reactive T-cells in patients with multiple-sclerosis: restricted T-cell receptor-V gene rearrangements and CDR3 sequence. European Journal of Immunology 25:958-968, 1995.
23. Jingwu Zhang and Jef Raus. Clonal depeletion of human myelin basic protein-reactive T cells by T cell vaccination. Annals of the New York Academy of Sciences 756: 323-326, 1995.
24. **Piet Stinissen, Caroline Vandevyver, Els Smeyers, Luc Vandegaer Jan Nies, Luc Tuyls, Robert Medaer, Jef Raus and Jingwu Zhang. Increased frequency of gamma-delta-T-cells in cerebrospinal-fluid and peripheral-blood of patients with multiple-sclerosis: reactivity, cytotoxicity, and T-cell receptor-V gene rearrangements. Journal of Immunology 154: 4883-4894, 1995.
25. Piet Stinissen, Caroline Vandevyver, Jef Raus and Jingwu Zhang. Superantigen reactivity of T cell clones isolated from patients with multiple sclerosis. Cellular Immunology 166: 227-235, 1995.
26. **Jingwu Zhang, Caroline Vandevyver, Piet Stinissen, Robert Medaer and Jef Raus. In-vivo clonotypic regulation of human myelin basic protein-reactive T-cells by T-cell vaccination. Journal of Immunology 155: 5868-5877, 1995.
27. Silva Markovic-Plese, Hikoaki Fukaura, Jingwu Zhang, Ahmad Al-Sabbagh, Scott Southwood, Alessandro Sette, Vijay Kuchroo, David Hafler. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. Journal of Immunology 155: 982-992, 1995.
28. ***Robert Medaer, Piet Stinissen, Luc Truyen and Jef Raus and Jingwu Zhang. Depletion of myelin-basic-protein autoreactive T-cells by T-cell vaccination – Pilot trial in multiple-sclerosis. Lancet 346: 807-808, 1995.
29. **Guy Hermans, Nadia Mertens, Lysiane Hauben, Piet Stinissen, Jef Raus and Jingwu Zhang. Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals. Annals of Neurology 42: 18-27, 1997.
30. *Linda Celis, Caroline Vandevyver, Piet Geusens, Jan Dequeker, Jef Raus and Jingwu Zhang. Clonal expansion of mycobacterial heat-shock protein-reactive T lymphocytes in the synovial fluid and blood of rheumatoid arthritis patients. Arthritis and Rheumatism 40:510-519, 1997.
31. Robert Medaer, Piet Stinissen, Jingwu Zhang, Jef Raus. Prospects for T cell vaccination in multiple sclerosis. Biodrugs 8:1-5, 1997.
32. *Milena Kozovska, Ying Zang, Iwan Aebischer, Victor Rivera, Wei Luo, Paul Crowe, Stefan Boehme, Jingwu Zhang. T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications. European Journal of Immunology 28: 1894-1901, 1998.
33. *Ying Zang, Milena Kozovska, Iwan Aebischer, Victor Rivera, Wei Luo, Paul Crowe, Stefan Boehme, Jingwu Zhang. Restricted TCR V alpha gene rearrangements in T cells recognizing an immunodominant peptide of myelin basic protein in DR2 patients with multiple sclerosis. International Immunology 10: 991-998, 1998.
34. *Piet Stinissen, Jingwu Zhang, Caroline Vandervyver, Guy Hermans and Jef Raus. Gamma delta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination. Journal of Neuroimmunology 87:94-104, 1998
35. Caroline Vandevyver, Kris Motmans, Piet Stinissen, Jingwu Zhang, Jef Raus. Cytokine mRNA profile of myelin basic protein reactive T-cell clones in patients with multiple sclerosis. Autoimmunity 28: 77-89, 1998.
36. *Ying C. Q. Zang, Milena Kozovska, Jian Hong, Savita Mann, Sufang Li, James M. Killian, Victor M. Rivera, Jingwu Zhang. Impaired apoptotic deletion of myelin basic protein-reactive T cells in patients with multiple sclerosis. European Journal of Immunology 29: 1692-1700, 1999.
37. *Kisco Kil, Ying C. Q. Zang, Deye Yang, Jian Hong, Sufang Li, James M. Killian, Victor M. Rivera, Jingwu Zhang. T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis. Journal of Neuroimmunology 98, 201-207, 1999.
38. *Milena E. Kozovska, Jian Hong, Ying C. Q. Zang, Victor Rivera, James Killian, Jingwu Zhang. Interferon beta induces T-helper 2 immune deviation in MS. Neurology 53: 1692-1697, 1999.
39. ** Jian Hong, Ying C. Q. Zang, Sufang Li, James M. Killian, Victor M. Rivera, Jingwu Zhang. A common TCR V-D-J sequence in V beta 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis. Journal of Immunology 163:3530-3538, 1999.
40. *Michael Pazara, Emanuela Gussoni, Ann Begovich, Ying Zang, Stanley Appel, Larry Steinman, Jingwu Zhang. T cell receptor V gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurobiology of Disease 6:392-405, 1999.
41. **Rana Singh, Ying, Zang, Sufang Li and Jingwu Zhang. Th1 and Th2 deviation of myelin-autoreactive T cells by altered peptide ligands is associated with reciprocal regulation of Lck, Fyn, and ZAP-70. Journal of Immunology 163, 6393-6402, 1999.
42. RA Hurley, K Taber, J Zhang and L Hayman. Neuropsychiatric presentation of multiple sclerosis. Journal of Neuropsychiatry Clin. Neurosci. 11: 5-7, 1999.
43. *Ying Zang, Milena Kozovska, Sufang Li, Savita Mann, James Killian, Victor Rivera, Jingwu Zhang. Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis. European Journal of Immunology 30: 908-913, 2000
44. **Ying Zang, Jian Hong, Victor M. Rivera, James M. Killian, Jingwu Zhang. Preferential recognition of TCR hypervariable regions by human anti-idiotypic T cells induced by T cell vaccination. Journal of Immunology 164: 4011-4017, 2000.
45. *Maria V. Tejada-Simon, Deye Yang, Ying Zang, Victor Rivera and Jingwu Zhang. Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis. International Immunology 12: 1641-1650, 2000.
46. *Ying Zang, Deye Yang, Jian Hong, Maria Tejada-Simon, Victor Rivera and Jingwu Zhang. Immunoregulation and blocking antibodies induced by interferon beta treatment in MS. Neurology 55: 397-404, 2000.
47. **Ying Zang, Ajoy K. Samanta, Jyotsnabaran B. Halder, Jian Hong, Victor Rivera, Jingwu Zhang. Aberrant T cell migration toward RANTES and MIP-1 alpha in patients with multiple sclerosis – Overexpression of chemokine receptor CCR5. Brain 123: 1874-1882, 2000.
48. **Jian Hong, Ying Zang, Victor M. Rivera, Jingwu Zhang. Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T cell vaccination. Journal of Immunology 165: 6858-6864, 2000.
49. *Ying Zang, Jyotsnabaran B. Halder, Ajoy K. Samanta, Jian Hong, Victor Rivera, Jingwu Zhang. Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1a by interferon-beta. Journal of Neuroimmunology 112: 174-180, 2001.
50. *Maria Tejada-Simon, Jian Hong, Victor Rivera, Jingwu Zhang. Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals. European Journal of Immunology 3: 907-917, 2001.
51. Godkin AJ, Smith KJ, Willis A, Tejada-Simon MV, Jingwu Zhang, Elliott T, Hill AV.J Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions. Journal of Immunology 166: 6720-6727, 2001.
52. Roland Schroers, Xue F. Huang, Juergen Hammer, Jingwu Zhang, Si-Yi Chen. Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-helper cells. Cancer Research 62: 2600-2605, 2002.
53. *Jingwu Zhang, Victor M. Rivera, Maria V. Tejada-Simon, Deye Yang, Jian Hong, Sufanfg Li, Hani Haykal, James Killian, Ying C.Q. Zang. T Cell Vaccination in Multiple Sclerosis: Results of a Preliminary Study. Journal of Neurology 249: 212-218, 2002.
54. *Jian Hong, Maria V. Tejada-Simon, Victor M. Rivera, Ying C.Q. Zang, Jingwu Zhang. Anti-Viral Properties of Interferon Beta Treatment in Patients with Multiple Sclerosis. Multiple Sclerosis 8: 237-242, 2002.
55. *Ying Zang, Jyotsnabaran Halder, Jian Hong, Victor M. Rivera, Jingwu Zhang. Regulatory effects of estriol on T cell migration and cytokine profile: inhibition of transcription factor NF-kappa B. Journal of Neuroimmunology 124:106-114, 2002.
56. **Maria Tejada-Simon, Jian Hong, Victor Rivera, James Killian, Ying Zang, Jingwu Zhang. Detection of viral DNA and immune responses to the human herpesvirus 6 101-kilodalton virion protein in patients with multiple sclerosis and in controls. Journal of Virology 76: 6147-6154, 2002.
57. *Maria Tejada-Simon, Jian Hong, Victor Rivera, and Jingwu Zhang. Skewed autoantibody reactivity to the extracellular domain of myelin oligodendrocyte glycoprotein in multiple sclerosis. Immunology 107:403-410, 2002.
58. **Ying C. Q. Zang, Jian Hong, Victor M. Rivera, James Killian, Jingwu Zhang. Human Anti-Idiotypic T Cells Induced by TCR Peptides Corresponding to a Common CDR3 Sequence Motif in Myelin Basic Protein-Reactive T Cells. International Immunology 15:1073-1080, 2003.
59. **Maria Tejada-Simon, Ying Zang, Jian Hong, Victor Rivera, and Jingwu Zhang. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Annals of Neurology 53:189-197, 2003.
60. *Hassan H Salama, Oldrich J Kolar, Ying C.Q. Zang and Jingwu Zhang. Effects of combination therapy of beta-interferon la and prednisone on serum immunologic markers in patients with multiple sclerosis. Multiple Sclerosis 9: 28-31, 2003.
61. *Ying Zang, Jian Hong, Rachel Robinson, Victor M. Rivera, Jingwu Zhang. Immune regulatory properties and interactions of Copolymer-I and beta-interferon 1a in multiple sclerosis. Journal of Neuroimmunology 137: 144-53, 2003.
62. **Hassan Salama, Ying Zang, Azza El-Mongui, Jingwu Zhang. Blocking effects of serum reactive antibodies induced by glatiramer acetate treatment in multiple sclerosis. Brain 126: 2638-2647, 2003.
63. Yingping Cao, Hong Zhou, Zexian Zheng, Ningli Li, Bo-hua Shen, Tsi-Siang Shih, Hong Jian, Jingwu Zhang, Kuang-Yen Chou. Keratinocytes induce local tolerance to skin graft by activating interleukin-10-secreting T cells in the context of co-stimulation molecule B7-H1. Transplantation 75: 1390-1396, 2003.
64. *Jian Hong, Ying C.Q. Zang, Sufang Li, Victor Rivera, Jingwu Zhang. Ex vivo detection of myelin basic protein-reactive T cells in multiple sclerosis and controls using specific TCR oligonucleotide probes. European Journal of Immunology 34:870-881, 2004.
65. **Ying C. Q. Zang, Sufang Li, Victor M. Rivera, Jian Hong, Rachel R. Robinson, Wini T. Breitbach, James Killian, Jingwu Zhang. Increased CD8+ Cytotoxic T Cell Responses to Myelin Basic Protein in Multiple Sclerosis. Journal of Immunology 172(8): 5120-5127, 2004.
66. **Wei Sun, Uday Popat, George Hutton, Ying CQ Zang, Geoffrey Land, Robert Krance, George Carrum, Geoffrey A. Land, Helen Heslop, Malcolm Brenner, Jingwu Zhang. Characteristics of T-cell receptor repertoire and myelin-reactive T cells reconstituted from autologous haematopoietic stem-cell grafts in multiple sclerosis. Brain 127(5):996-1008, 2004.
67. Qishui Ou, Lin Lin, Lidong Huang, Fuxiang Chen, Kegui Wu, Peihua Lu, Jingwu Zhang, Kuang-Yen Chou. Persistence of MHC DR Nonexpression on Swine Cells by Introduction of a Mutated MHC Class II Transactivator Gene: A Comparison with the Effect Induced by Antisense RNA. Journal of Clinical Immunology 24(1):97-106, 2004.
68. *Jian Hong, Ying Zang, George Hutton, Victor M. Rivera, Jingwu Zhang. Gene expression profiling of relevant biomarkers for treatment evaluation in multiple sclerosis. Journal of Neuroimmunology 152: 126-139, 2004.
69. *Ying C.Q. Zang, Sheri M. Skinner, Rachel R. Robinson, Sufang Li, Victor M. Rivera, George J. Hutton, Jingwu Zhang. Regulation of differentiation and functional properties of monocytes and monocyte-derived dendritic cells by interferon beta in multiple sclerosis. Multiple Sclerosis 10(5): 499-506(8), 2004.
70. **Rana AK Singh and Jingwu Zhang. Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand. Journal of Immunology 173(12): 7299-307, 2004.
71. **Wei Sun, Hong Nie, Ningli Li, Ying Zang, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Sarvamangala Prasad, Rachel R Robinson, Walter Ho, Eli Sercarz, Jingwu Zhang. Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis. Genes and Immunity 6: 248-261, 2005.
72. *Guangwu Xu, Wei Sun, Dongyi He, Li Wang, Wenxin Zheng, Hong Nie, Liqing Ni, Dongqing Zhang, Ningli Li, Jingwu Zhang. Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism. Journal of Rheumatology 32(3): 410-6, 2005.
73. **Guangwu Xu, Hong Nie, Ningli Li, Wenxin Zheng, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Jian Hong, Jingwu Zhang. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. Journal of Clinical Investigation 115(4):1060-1067, 2005.
74. **Jian Hong, Ningli Li, Xuejun Zhang, Biao Zheng, Jingwu Zhang. Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proceedings of the National Academy of Sciences USA 102(18): 6449-6454, 2005.
75. Qingwei Luo, Yun Ding, Kurt Watson, Jingwu Zhang, Guo-Huang Fan. N-Methyl-D-aspartate Attenuates CXCR2-Mediated Neuroprotection through Enhancing the Receptor Phosphorylation and Blocking the Receptor Recycling. Molecular Pharmacology 68:528-537, 2005.
76. Jian Qiu, Xiao-hui Wei, Fang Geng, Rui Liu, Jingwu Zhang, Yu-hong Xu. Multivesicular liposome formulations for the sustained delivery of interferon α-2b. Acta Pharmacologica Sinica 26(11):1395-1401, 2005.
77. Zhong-Ping Lu, Zhong-Liang Ju, Guang-Yin Shi, Jingwu Zhang, Jian Sun. Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. BBRC 330(1):204-209, 2005.
78. **Jian Hong, Ying C. Q. Zang, Hong Nie, Jingwu Zhang. CD4+ Regulatory T Cell Responses Induced by T Cell Vaccination in Patients with Multiple Sclerosis. Proceedings of the National Academy of Sciences USA 103:5024-5029, 2006.
79. **Zhaojun Wang, Jian Hong, Wei Sun, Guangwu Xu, Ningli Li, Xi Chen, Ailian Liu, Lingyun Xu, Bing Sun, Jingwu Zhang. Role of Gamma-Interferon in Induction of Foxp3 and Conversion of CD4+CD25- T cells to CD4+ Regulatory T Cells. Journal of Clinical Investigation 116(9):2434-2441, 2006.
80. **Bing Wan, Hong Nie, Ailian Liu, Guozhang Feng, Dongyi He, Rong Xu, Qi Zhang, Chen Dong, Jingwu Zhang. Aberrant Regulation of Synovial T Cell Activation by Soluble Co-Stimulatory Molecules in Rheumatoid Arthritis. Journal of Immunology 177(12):8844-8850, 2006.
81. **Wei Sun , Ying C. Q. Zang, Xin Liu, Jingwu Zhang. Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis. International Immunology 18(12):1691-1700, 2006.
82. Yun Ding, Mika Li, Jinwu Zhang, Ningli Li, Zongqin Xia, Yaer Hu, Sunxin Wang, Guo-Huang Fan. The 73-kDa Heat Shock Cognate Protein is a CXCR4 Binding Protein that Regulates the Receptor Endocytosis and the Receptor-Mediated Chemotaxis. Molecular Pharmacology 69(4):1269-79, 2006.
83. Runsheng Li, Cherry Luo, Marjelo Mines, Jingwu Zhang, Guo-Huang Fan. Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain. Journal of Biological Chemistry 281:37616-37627, 2006.
84. Zi-Heng Zhuang, Lei Sun, Ling Kong, Jun-Hao Hu, Ming-Can Yu, Peter Reinach, Jingwu Zhang, Bao-Xue Ge. Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cellular Signalling 18(7):964-70, 2006.
85. Xiaodong Wu, Wanqiu Hou, Shuhui Sun, Enguang Bi, Yuan Wang, Mude Shi, Jingwu Zhang, Chen Dong, Bing Sun. Novel function of IFN-g , negative regulation on Dendritic Cell migration and T cell priming. Journal of Immunology 15;177(2):934-943, 2006.
86. Li Wang, Fang Du, Qi Cao, Huiming Sheng, Baihua Shen, Yan Zhang, Yingna Diao, Jingwu Zhang, Ningli Li. Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45. Cell Research 16(8):702-712, 2006.
87. Lingqiao Zhu, Fang Ji, Yuan Wang, Yi Zhang, Qiang Liu, Jingwu Zhang, Kouji Matsushima, Qi Cao, Yanyun Zhang. Synovial Autoreactive T Cells in Rheumatoid Arthritis Resist IDO-Mediated Inhibition. Journal of Immunology 177: 8226-8233, 2006.
88. Cherry Luo, Heng Pan, Marjelo Mines, Kurt Watson, Jingwu Zhang, Guo-Huang Fan. CXCL12 induces tyrosine phosphorylation of cortactin which plays a role in CXCR4-mediated extracellular signal regulated kinase activation and chemotaxis. Journal of Biological Chemistry 281(40):30081-93, 2006.
89. Jiawei Lu, Zhenyu Lu, Jingwu Zhang, Wei Dai, Luo Lu, Ming Xu. TGF-ß2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation. Experimental Cell Research 312(18):3631-3640, 2006.
90. ***Guangjie Chen, Ningli Li, Ying C. Q. Zang, Dongqing Zhang, Dongyi He, Guozhang Feng, Liqing Ni, Rong Xu, Li Wang, Baihua Shen, Jingwu Zhang. Vaccination With Selected Synovial T Cells in Rheumatoid Arthritis. Arthritis and Rheumatism 56(2), 453–463, 2007.
* This paper is accompanied with an Editorial published in the same issue:
Brent Prakken and Salvatoire Albani. Exploiting T cell crosstalk as a vaccination strategy for rheumatoid arthritis. Arthritis and Rheumatism 56, 389-392, 2007
91. *Guilin Yang, Ailian Liu, Qing Xie, Taylor B. Guo, Bing Wan, Boping Zhou, Jingwu Zhang. Association of CD4+CD25+Foxp3+ Regulatory T Cells with Chronic Activity and Viral Clearance in Patients with Hepatitis B. International Immunology 19(2):133-40, 2007.
92. **Jingwu Zhang. Yin and Yang interplay of IFN-gamma in inflammation and autoimmune disease. Journal of Clinical Investigation 117(4):871-3, 2007.
93. **Zhaojun Wang, Ju Qiu, Ailian Liu, Taylor B Guo, Ying Wang, Yin Li, Jingwu Zhang. Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis. Journal of Immunology 179: 5958–5965, 2007.
94. **Yufeng Shi, Yan Feng, Jiuhong Kang, Chang Liu, Zhenxin Li, Dangsheng Li, Wei Cao, Ju Qiu, Zhengliang Guo, Enguang Bi, Lei Zang, Chuanzhen Lu, Jingwu Zhang* (Co-corresponding author), Gang Pei. Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1. Nature Immunology 8: 817-824, 2007.
95. Zhong L. Ju, Gui Y. Shi, Jin X. Zuo, Jingwu Zhang, Jian Sun. Unexpected development of autoimmunity in BAFF-R-mutant MRL-lpr mice. Immunology 120(2):281-9, 2007.
96. Jun-hao Hu, Ting Chen, Zi-heng Zhuang, Ling Kong, Ming-Can Yu, Yusen Liu, Jingwu Zhang, Bao-Xue Ge. Feedback control of MKP-1 expression by p38. Cellular Signalling 19(2):393-400, 2007.
97. Hong Zhou, Zhijun Jiao, Jijun Pana, Jian Hong, Jiaxian Tao, Ningli Li, Yun Zhou, Jingwu Zhang, Kuang-Yen Chou. Immune suppression via IL-4/IL-10-secreting T cells: A nontoxic property of anti-HIV agent Trichosanthin. Clinical Immunology 122(3):312-22, 2007
98. Qi Cao, Li Wang, Fang Du, Huiming Sheng, Yan Zhang, Juanjuan Wu, Baihua Shen, Tianwei Shen, Jingwu Zhang, Dangsheng Li, Ningli Li. Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells. Cell Research 17:627-637, 2007
99. Y. L. Yang, Q. Duan, T. B. Guo, X. X. Wang, Q. Ruan, G. T. Xu, J. W. Zhang, Z. Y. Lu, M. Xu, L. Lu, W. Dai. BubR1 deficiency results in enhanced activation of MEK and ERKs upon microtubule stresses. Cell Proliferation 40: 397-410, 2007
100. **Yiping Ren, Limin Lu, Taylor B. Guo, Ju Qiu, Yiqing Yang, Ailian Liu, Jingwu Zhang. Novel Immunomodulatory Properties of Berbamine through Selective Down-Regulation of STAT4 and Action of IFN- in Experimental Autoimmune Encephalomyelitis. Journal of Immunology 181:1491-1498, 2008
101. Yun Ding, Li Zhang, J. Shawn Goodwin, Ziqing Wang, Bingdong Liu, Jingwu Zhang, Guo-Huang Fan. Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1 infection. Experimental Cell Research 314(3):590-602, 2008
102. Ziqing Wang, Li Zhang, Aimin Qiao, Kurt Watson, Jingwu Zhang, Guo-Huang Fan. Activation of CXCR4 triggers ubiquitination and down-regulation of MHC-I on epitheloid carcinoma HeLa cells. Journal of Biological Chemistry 283(7):3951-9, 2008
103. Heng Pan, Cherry Luo, Runsheng Li, Aimin Qiao, Li Zhang, Marjelo Mines, Alfred M. Nyanda, Jingwu Zhang, Guo-Huang Fan. Cyclophilin A Is Required for CXCR4-mediated Nuclear Export of Heterogeneous Nuclear Ribonucleoprotein A2, Activation and Nuclear Translocation of ERK1/2, and Chemotactic Cell Migration. Journal of Biological Chemistry 283(1):623-37, 2008
104. Ming-Can Yu, Liu-Li Su, Lin Zou, Ye Liu, Na Wu, Ling Kong, Zi-Heng Zhuang, Lei Sun, Hai-Peng Liu, Jun-Hao Hu, Dangsheng Li, Jack L Strominger, Jingwu Zang, Gang Pei, Bao-Xue Ge. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nature Immunology 9(8):898-907, 2008.
105. Fang Du, Li Wang, Yan Zhang, Wei Jiang, Huiming Sheng, Qi Cao, Juanjuan Wu, Baihua Shen, Tianwei Shen, Jingwu Zhang, Chunde Bao, Dangsheng Li, Ningli Li. Role of GADD45β in the regulation of synovial fluid T cell apoptosis in rheumatoid arthritis. Clinical Immunology 128(2):238-47, 2008.
106. Biao Zheng, Kirsten Switzer, Ekaterina Marinova, Jingwu Zhang, Shuhua Han. Exacerbation of autoimmune arthritis by copolymer-I through promoting type 1 immune response and autoantibody production. Autoimmunity 41(5):363-71, 2008.
107. Shan He, Qi Cao, Yuhua Qiu, Jianqing Mi, Jingwu Zhang, Min Jin, Hailiang Ge, Stephen G. Emerson, Yi Zhang, Yanyun Zhang. A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3 neutralizing antibody. Journal of Immunology 181: 7581-7592, 2008
108. **Wenxin Zheng, Runsheng Li, Heng Pan, Dongyi He, Rong Xu, Taylor B. Guo, Yajun Guo, Jingwu Zhang. Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis. Arthritis and Rheumatism 60(7):1957-1965, 2009
109. **Chunhua Chen, Xuebin Liu, Bing Wan, Jingwu Zhang. Regulatory properties of copolymer I in Th17 differentiation by altering STAT3 phosphorylation. Journal of Immunology 183(1):246-53, 2009
110. Guoliang Cui, Yuebo Zhang, Zhenwei Gong, Jingwu Zhang, Ying Qin Zang. Induction of CD4+CD25+Foxp3+ regulatory T cell response by glatiramer acetate in type 1 diabetes. Cell Research 19(5):574-83, 2009
111. Meiyue Chen, Guangjie Chen, Hong Nie, Xin Zhang , Xiaoyin Niu , Ying C. Q. Zang , Sheri M. Skinner , Jingwu Zhang, James M. Killian, Jian Hong. Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS. European Journal of Immunology 39(9):2525-36, 2009
112. *Jian Hong, Haiyan Li, Meiyue Chen, Ying C. Q. Zang, Sheri M. Skinner, James M. Killian, Jingwu Zhang. Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis. International Immunology, 21(12):1329-1340, 2009
113. **Xi Chen, Lei Fang, Shengli Song, Taylor B Guo, Ailian Liu, Jingwu Zhang. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway. Journal of Immunology, 183(10):6135-44, 2009
114. Ling Kong, Lei Sun, Hongxin Zhang, Qin Liu, Ye Liu, Linhua Qin, Guojun Shi, Jun-Hao Hu, Ajing Xu, Yue-Ping Sun, Dangsheng Li, Yu-Fang Shi, Jingwu Zhang, Jiang Zhu, Zhu Chen, Zhu-Gang Wang, Bao-Xue Ge. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host & Microbe, 6:150-161, 2009.
115. ***Xuebin Liu, Stewart Leung, Chunxia Wang, Ji Wang, Bing Wan, Zhu Tan,Taylor Guo, Lei Fang, Yonggang Zhao, Xia Qin, Limin Lu, Runsheng Li, Heng Pan, Mingjuan Song, Ailian Liu, Jian Hong, Hongtao Lu, Jingwu Zhang. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nature Medicine, 16(2):191-197, 2010.
116. *Gaochao Qian, Xia Qin, Ying Zang, Baoxue Ge, Taylor Guo, Bing Wan, Jingwu Zhang. High doses of alpha-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 differentiation. Cell Research, 20:480-491, 2010.
117. Xiaoyin Niu, Dongyi He, Xin Zhang, Tao Yue, Ningli Li, Jingwu Zhang, Chen Dong, Guangjie Chen. IL-21 regulates Th17 cells in rheumatoid arthritis. Human Immunology, 71(4):334-41, 2010.
118. **Xia Qin, Taylor Guo, Bing Wan, Lei Fang, Limin Lu, Lili Wu, Ying Zang, Jingwu Zhang. Regulation of Th1 and Th17 Cell Differentiation and Amelioration of EAE by Natural Product Compound Berberine. Journal of Immunology, 185(3):1855-63, 2010.
119. **Guangjie Chen, Xin Zhang, Runsheng Li, Lei Fang, Xiaoyin Niu, Yingxia Zheng, Dongyi He, Rong Xu, Jingwu Zhang. Role of Osteopontin in Synovial Th17 Differentiation in Rheumatoid Arthritis. Arthritis and Rheumatism, 62(10):2900-8, 2010
120. Guoliang Cui, Xia Qin, Lili Wu, Yuebo Zhang, Xiaoyan Sheng, Qiwen Yu, Hongguang Sheng, Beili Xi, Jingwu Zhang, Ying Qin Zang. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. Journal of Clinical Investigation, 121(2):658–670, 2011
121. **Wei Cao, Yiqing Yang, Zhengyi Wang, Ailian Liu, Lei Fang, Fenglan Wu, Jian Hong, Yufang Shi, Stewart Leung, Chen Dong, Jingwu Zhang. Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease. Immunity, 35:1-12. 2011
122. Xiaoyin Niu, Dongyi He, Shaohua Deng, Weiyi Li, Yebin Xi, Changyi Xie, Ting Jiang, Jingwu Zhang, Chen Dong, Guangjie Chen. Regulatory immune responses induced by IL-1 receptor antagonist in rheumatoid arthritis. Molecular Immunology 49(1-2):290-6, 2011
123. ***Hong Nie, Yingxia Zheng, Runsheng Li, Taylor Guo, Dongyi He, Lei Fang, Xuebin Liu, Lianbo Xiao, Xi Chen, Bing Wan, Eugene Chin, Jingwu Zhang. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. Nature Medicine, 19(3):322-8, 2013
124. Qi Zhang, Feifei Cui, Lei Fang, Jian Hong, Biao Zheng, Jingwu Zhang. TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway. J Mol Cell Biol. 5(2):85-98, 2013
综述及专著
1. Jingwu Zhang, Howard Weiner and David Hafler
Autoreactive T cells in multiple sclerosis (Invited review)
International Review of Immunology 9:183-201, 1992.
2. Jingwu Zhang and Jef Raus (Book Editor)
T cell vaccination in autoimmune diseases: from laboratory to clinic
Human Immunology 38:87-96, 1993.
3. Jingwu Zhang and Jef Raus
T cell vaccination in multiple sclerosis: hopes and facts (Invited review)
Acta Neurologica Belgica 94:112-115, 1994.
4. Jingwu Zhang and Jef Raus
Myelin basic protein-reactive T cells in multiple sclerosis: pathologic relevance and therapeutic targeting (Invited review)
Cytotechnology 16:181-187, 1994.
5. Jingwu Zhang and Jef Raus (Book Editor)
T cell vaccination and Autoimmune disease, Springer-Verlag, Landes Medical Publishers, Austin, USA. 1995.
6. Jingwu Zhang
Multiple sclerosis: perspectives on autoimmune pathology and prospects for therapy
In Current Neurology S. Appel (Ed.). Mosby-Year Book, Chicago, USA. 15:115-155, 1995.
7. Jingwu Zhang, Piet Stinissen, Robert Medaer and Jef Raus
T cell vaccination: clinical application in autoimmune diseases (Invited review)
Journal of Molecular Medicine 74:653-662, 1996
8. Jingwu Zhang and Jef Raus
T cell vaccination in multiple sclerosis (Invited review)
Multiple Sclerosis 1:353-356, 1996.
9. Piet Stinissen, Jingwu Zhang, Robert Medaer, Caroline Vandervyver and Jef Raus
Vaccination with autoreactive T cell clones in multiple sclerosis: Overview of immunological and clinical data (Invited review)
Journal of Neuroscience Research 45:500-511, 1996
10. Piet Stinissen, Jef Raus and Jingwu Zhang
Autoimmune pathogenesis of multiple sclerosis: Role of autoreactive T lymphocytes and new immunotherapeutic strategies (Invited review)
Critical Reviews in Immunology 17:33-75, 1997
11. Jingwu Zhang, Victor Rivera, Jef Raus and Lawrence Steinman
New treatments for multiple sclerosis.
in Current Neurology. S. Appel (ed).-Year Book, IOS Press-Ohmsha, Amsterdam, 17:157-184, 1997.
12. Piet Stinissen, Jingwu Zhang, Caroline Vandervyver and Jef Raus
Autoreactive T lymphocytes in multiple sclerosis: Pathologic role and therapeutic targeting. (Invited review)
in Neurochemistry and neuroimmunology of EAE; implications for therapy of MS., Teelken and Korf (Eds.), Plenum Press, New York, pp 113-119, 1997
13. Jingwu Zhang (Book Editor)
Textbook Of Neuroimmunology: Immunotherapy in Neuroimmunologic Diseases. Taylor & Francis Ltd, UK, 1998.
14. Jingwu Zhang, Piet Stinissen, Robert Medaer, Luc Truyen and Jef Raus
T cell vaccination for the treatment of multiple sclerosis
In Textbook Of Neuroimmunology: Immunotherapy in Neuroimmunologic Diseases. Jingwu Zhang, et al. (eds.), Taylor & Francis Ltd, UK, pp 215-232, 1998
15. Jingwu Zhang
Emerging therapeutic targets in multiple sclerosis: Suppression and elimination of myelin-autoreactive T lymphocytes (Invited review).
In: Expert Opinion on Therapeutic Targets, Informa Healthcare Publishers, London, 2: 137-156, 1998
16. Paul Conlon, Jorge Oksenberg, Jingwu Zhang and Lawrence Steinman
The Immunobiology of Multiple Sclerosis: An Autoimmune Disease of the Central Nervous System (Invited review).
Neurobiology of Disease 6:149-166, 1999
17. Gholam Motamedi and Jingwu Zhang
Demyelinating and inflammatory diseases.
In Neurology Pearls of Wisdom, M. Labanowski, Ed., Boston Medical Publishing Corp., Boston, pp 63-76, 1999.
18. Ariel Miller and Jingwu Zhang
T cell vaccination and antigen-driven immunotherapy for multiple sclerosis (Invited chapter)
In Multiple Sclerosis: Tissue destruction and repair. Kappos et al., (eds). Martin Dunitz Publishers, London, pp 233-244, 2001.
19. *Jingwu Zhang
T cell vaccination in multiple sclerosis: Immunoregulatory mechanism and prospects for therapy (Invited review)
Critical Reviews in Immunology 21:41-55, 2001
20. Vipin Kumar, Eli Sercarz, Jingwu Zhang and Irun Cohen
T cell vaccination: From basics to the clinic (Invited review).
Trends in Immunology 22:539-540, 2001
21. Jingwu Zhang
Clinical application of T cell vaccination: Clinical trials in multiple sclerosis (Invited chapter).
In Autoimmunity and Emerging Diseases. L. Steinman (ed). Bialik Institute, Jerusalem, pp 285-296, 2001.
22. Jingwu Zhang
T Cell Vaccination for Autoimmune Disease: Immunologic Lessons and Clinical Experience in Multiple Sclerosis (Invited review)
Expert Review of Vaccines 1:285-292, 2002.
23. Jingwu Zhang, George Hutton and Ying Zang
A comparison of the mechanisms of action of interferon beta and glatiramer acetate in the treatment of multiple sclerosis (Invited review)
Clinical Therapeutics 24:1998-2021, 2002
24. Jingwu Zhang
T Cell Autoimmunity and T Cell Vaccination (Invited review).
Current Trends in Immunology 4: 87-94, 2002
25. Jingwu Zhang and George Hutton
Therapeutic targets for the treatment of MS (Invited chapter).
In Treatment and Management of Multiple Sclerosis Ed. F. Columbus, Nova Science Publishers, pp. 107-153, 2005
26. Jingwu Zhang
T cell vaccination as an immunotherapy for autoimmune diseases.
Cellular and Molecular Immunology 1(5):321-7, 2004
27. Jingwu Zhang, George Hutton and Gholam Motamedi
Demyelinating and inflammatory diseases.
In Neurology Pearls of Wisdom. M. Labanowski, Ed., Boston Medical Publishing Corp., Boston, 2004.
28. **Jingwu Zhang and George Hutton.
Role of magnetic resonance imaging and immunotherapy in treating multiple sclerosis (Invited review).
Annual Review of Medicine 56:273-302, 2005
29. Jingwu Zhang
Paradoxical roles of interferon-γ in autoimmune disease (Invited review)
Expert Review of Clinical Immunology 3(1):35-38, 2007
30. **Jingwu Zhang (Book Editor).
T Cell Vaccination in Autoimmune Disease
In Immune Regulation and Immunotherapy in Autoimmune Disease. Springer International, New York., pp339-368, 2007
31. Sheri Skinner, Ying Qin Zang, Jian Hong and Jingwu Zhang.
T cell vaccination for multiple sclerosis (Invited chapter)
In Neuroimmunology Research Focus, P.V. Broglio, (Ed.); Nova Science Publishers, Inc., Hauppauge, N.Y., pp 139-157, 2007
32. Jingwu Zhang
CD4+ regulatory T cells induced by T cell vaccination (Invited chapter)
Current Topics in Neuroimmunology, Tabira (Ed.), 2007
33. Jian Hong, Sheri Skinner and Jingwu Zhang
Induction of adaptive CD4+CD25+FoxP3+ Regulatory T cell response in autoimmune disease (Invited chapter)
In Regulatory T Cells and Clinical Application, Shuiping Jiang (Ed.), Springer Science & Business Media, LLC, pp 293-305, 2008
34. Jingwu Zhang and Irun R Cohen (Book Editor)
Regulatory Mechanisms Induced by T cell Vaccination in Humans
In T cell vaccination, Nova Science Publishers, Hauppauge, N.Y., pp 39-57, 2008
35. Stewart Leung, Xuebin Liu, Lei Fang, Xi Chen, Taylor Guo, Jingwu Zhang
The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease (Invited review)
Cellular and Molecular Immunology, 7(3):182-189, 2010
36. Xuebin Liu, Stewart Leung, Lei Fang, Xi Chen, Taylor Guo, Jingwu Zhang
Interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease: A tale of Yin and Yang (Invited chapter).
In TH17 Cells in Health and Disease, Shuiping Jiang (Ed.), Springer New York, 2011
37. Jian Hong, Zhengyi Wang, Lei Shen, Jingwu Zhang
Macrophage Polarization in the Course and Treatment of Autoimmune Disease (Invited chapter).
In Handbook of Macrophages: Life Cycle, Functions and Diseases, Rikiya Takahashi and Hibiki Kai (Ed.), Nova Science Publishers, Inc., 2012
38. Xuebin Liu, Lei Fang, Taylor Guo, Hongkang Mei, Jingwu Zhang. (Invited review)
Drug targets in the cytokine universe for autoimmune disease. Trends in Immunology, 34(3):120-128, 2013